Antioxidant Therapy Reduces Oxidative Stress, Restores Na,K-ATPase Function and Induces Neuroprotection in Rodent Models of Seizure and Epilepsy: A Systematic Review and Meta-Analysis

Epilepsy is a neurological disorder characterized by epileptic seizures resulting from neuronal hyperexcitability, which may be related to failures in Na,K-ATPase activity and oxidative stress participation. We conducted this study investigate the impact of antioxidant therapy on stress, activity, seizure factors, mortality rodent seizure/epilepsy models induced pentylenetetrazol (PTZ), pilocarpine (PILO), kainic acid (KA). After screening 561 records MEDLINE, EMBASE, Web Science, Science Direct, Scopus databases, 22 were included systematic review following PRISMA guidelines. The meta-analysis 14 studies showed that animals there was an increase oxidizing agents nitric oxide (NO) malondialdehyde (MDA), with reduction endogenous antioxidants reduced glutathione (GSH) superoxide dismutase (SO). all areas evaluated. Antioxidant reversed these parameters altered or epilepsy induction. In addition, percentage decrease number mortality, longer latency using therapy. Thus, suggests use promotes neuroprotective effects mitigates epilepsy. protocol registered Prospective Register Systematic Reviews (PROSPERO) CRD42022356960.